Protein Design (Methods in Molecular Biology)

Protein layout: equipment and functions provides the main updated protein layout and engineering recommendations in order that readers can adopt their very own tasks with a greatest probability of good fortune.

The authors current built-in computational methods that require a number of levels of computational complexity, and the foremost accomplishments which were completed within the layout and structural characterization of helical peptides and proteins.

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Karle, I. L. , and Balaram, P. (1996) Ambidextrous molecules: cylindrical peptide buildings shaped by way of fusing left- and right-handed helices. Biopolymers 39, 279–285. 27. Karle, I. L. (2001) Controls exerted by way of the Aib residue: helix formation and helix reversal. Biopolymers (Pept. Sci. ) 60, 351–365. layout of Secondary constitution versions ninety three 28. Aravinda, S. , Shamala, N. , Desiraju, S. , and Balaram, P. (2002) A correct passed peptide helix containing a principal double D-amino acid phase. Chem. Commun. 2454–2455. 29. Karle, I. L. , Gopi, H. N. , and Balaram, P. (2003) Crystal constitution of a hydrophobic 19-residue peptide helix containing 3 centrally positioned D amino acids. Proc. Natl. Acad. Sci. united states a hundred, 13946–13951. 30. Awasthi, S. ok. , Raghothama, S. , and Balaram, P. (1995) A designed β-hairpin peptide. Biochem. Biophys. Res. Commun. 216, 375–381. 31. Karle, I. L. , Awasthi, S. okay. , and Balaram, P. (1996) A designed β-hairpin peptide in crystals. Proc. Natl. Acad. Sci. united states ninety three, 8189–8193. 32. Raghothama, S. , Awasthi, S. okay. , and Balaram, P. (1998) β-hairpin nucleation by way of Pro-Gly β-turns. comparability of D-Pro-Gly and L-Pro-Gly sequences in apolar octapeptides. J. Chem. Soc. Perkin Trans. 2, 137–143. 33. Das, C. , Naganagowda, G. A. , Karle, I. L. , and Balaram, P. (2001) Designed βhairpin peptides with outlined tight flip stereochemistry. Biopolymers fifty eight, 335–346. 34. Haque, T. S. and Gellman, S. H. (1997) Insights on β-hairpin balance in aqueous answer from peptides with enforced style I' and sort II' β-turns. J. Am. Chem. Soc. 119, 2303–2304. 35. Espinosa, J. F. and Gellman, S. H. (2000) A designed β-hairpin containing a ordinary hydrophobic cluster. Angew. Chem. Int. Ed. Engl. 39, 2330–33. 36. Stanger, H. E. and Gellman, S. H. (1998) ideas for antiparallel β-sheet layout: D-Pro-Gly is enhanced to L-Asn-Gly for β-hairpin nucleation. J. Am. Chem. Soc. a hundred and twenty, 4236–4237. 37. Aravinda, S. , Harini, V. V. , Shamala, N. , Das, C. , and Balaram, P. (2004) constitution and meeting of designed β-hairpin peptides in crystals as versions for β-sheet aggregation. Biochemistry forty three, 1832–1846. 38. Gellman, S. H. (1998) minimum version platforms for β-sheet secondary constitution in proteins. Curr. Opin. Chem. Biol. 2, 717–725. 39. Blanco, F. , Ramirez-Alvarado, M. , and Serrano, L. (1998) Formation and balance of β-hairpin constructions in polypeptides. Curr. Opin. Struct. Biol. eight, 107–111. forty. Aravinda, S. , Shamala, N. , Rai, R. , Gopi, H. N. , and Balaram, P. (2002) A crystalline β-hairpin peptide nucleated through a sort I' Aib-D-Ala β-turn: facts for crossstrand fragrant interactions. Angew. Chem. Int. Ed. Engl. forty-one, 3863–3865. forty-one. Harini, V. V. , Aravinda, S. , Rai, R. , Shamala, N. , and Balaram, P. (2005) Molecular conformation and packing of peptide β-hairpins in crystals. buildings of 2 man made octapeptides containing 1-aminocycloalkane-1-carboxylic acid residues on the i+2 place of the β-turn. Chem. Eur. J. In press. forty two. Das, C. , Raghothama, S. , and Balaram, P. (1998) A designed 3 stranded βsheet peptide. J. Am. Chem. Soc. a hundred and twenty, 5812–5813. forty three. Das, C. , Raghothama, S. , and Balaram, P. (1999) A 4 stranded β-sheet constitution in a designed artificial polypeptide.

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