More Than Human: Embracing the Promise of Biological Enhancement

By Ramez Naam

Publish yr note: First released 2005

• What for those who should be smarter, greater, and feature a greater reminiscence simply by taking a pill?
• What if shall we adjust our genes to medication Alzheimer's and Parkinson's?
• What if shall we halt or maybe opposite the human getting older process?
• What if lets converse with one another just by brooding about it?

These questions have been as soon as the stuff of technological know-how fiction. this day, advances in biotechnology have proven that they're believable, even prone to be comprehensive within the close to destiny. In labs all over the world, researchers searching for how one can support the in poor health and injured have stumbled onto thoughts that increase fit animals--making them superior, speedier, smarter, and longer-lived--in a few circumstances, even connecting their minds to robots and pcs around the Internet.

Now technological know-how is at the verge of using this information to fit women and men, permitting us to change humanity in methods we'd formerly in simple terms dreamed attainable. an identical learn which can therapy Alzheimer's is resulting in medicinal drugs and genetic suggestions which can develop human intelligence. The options being built to stave off middle affliction and melanoma have the aptitude to gradual or perhaps opposite human getting older. And mind implants that repair movement to the paralyzed and sight to the blind are already permitting a small set of sufferers to regulate robots and desktops just by considering it.

Not each person welcomes this clinical growth. Cries of "against nature" come up from skeptics while scientists holiday new flooring at an staggering speed. around the political spectrum, the talk roils: should still we include the ability to change our minds and our bodies, or should still we limit it?

Distilling the main radical accomplishments being made in labs around the world, together with gene remedy, genetic engineering, stem phone examine, lifestyles extension, brain-computer interfaces, and cloning, greater than Human deals a thrilling travel of the influence biotechnology can have on our lives. all through this awesome journey, writer Ramez Naam stocks an impassioned imaginative and prescient for the longer term with revealing perception into the moral dilemmas posed by way of twenty-first-century science.

Winnder of the 2005 H.G. Wells Award

"A wonderful survey of present paintings and destiny chances in gene remedy, neurotechnology and different fields."
Los Angeles Times

"Ramez Naam presents a competent and trained cook's travel of the realm we would pick out if we choose that we should always fast-forward evolution. I disagree with nearly all his enthusiasms, yet i believe he has made his case cogently and well."
Bill McKibben, writer sufficient: Staying Human in an Engineered Age

"More Than Human is a type of infrequent books that's either a pleasant learn and an immense assertion. nobody drawn to the long run intersections of technology, know-how, and medication can have enough money to overlook this book."
Steven Johnson, writer of brain large Open and the place sturdy principles Come From

"More Than Human is superb - passionate but balanced, basically written and wealthy with attention-grabbing information. a superb evaluation of an issue that may dominate the twenty-first century."
Greg undergo, writer of useless strains and Darwin's Children

"The destiny speeds up and alter is upon us. the single query - requested cogently in additional Than Human - is whether or not we will learn how to trip the waves, otherwise be swept away. This e-book is a how-to advisor for future-wave riders."
David Brin, writer of life and The obvious Society: Will expertise Make Us choose from privateness and Freedom?

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S. division of schooling, nationwide heart for schooling records, may possibly sixteen, 2002 bankruptcy four sixty nine In 1900 a guy: Hayflick L. How and why we age. Exp Gerontol. 1998 Nov-Dec; 33(7-8): 639-53. evaluate. 70 “if, certainly, we have been to discover a treatment for cancer”: The President's Council on Bioethics. length of existence: Is There a organic guaranty interval? Testimony given on 12 December 2002 to the PCB by way of S. Jay Olshansky. on hand at http://www. bioethics. gov/transcripts/dec02/session2. html seventy one $3. 6 Billion: Entrepreneur journal, January 2001 seventy two place paper on human getting older: S. Jay Olshansky, Leonard Hayflick and Bruce A. Carnes, the reality approximately Human getting older, medical American, may well thirteenth 2002, seventy two “in the prior few years”: Lithgow remark at Anti-Aging Drug Discovery Summit, October 2002, San Francisco CA seventy two Andrzej Bartke: Bartke et al, Extending the lifespan of long-lived mice, Nature, VOL 414, 22 NOVEMBER 2001 seventy three a unmarried gene may possibly double the lifespan: Johnson TE. elevated existence span of age-1 mutants in Caenorhabditis elegans and reduce Gompertz fee of getting older. technological know-how. 1990;249:908-912 seventy three “worms have a hundred million nucleotides”: Steve Austad testimony to PCBE, December twelfth 2002, http://www. bioethics. gov/december02/session1. html seventy three “my preliminary findings”: e mail interview with Tom Johson seventy four A finished database of genetic adjustments which extend animal lifespan should be locate at technology Magazine’s SAGE KE. http://sageke. sciencemag. org/ seventy five extra immune to the exterior rigidity: Lithgow GJ, White TM, Melov S, Johnson TE. Thermotolerance and prolonged life-span conferred via single-gene mutations and precipitated by means of thermal pressure. Proc Natl Acad Sci U S A. 1995 Aug 1;92(16):7540-4 seventy five additional resistance to stresses: Oxidants, oxidative pressure and the biology of getting old, Toren Finkel & Nikki J. Holbrook, NATURE VOL 408, nine NOVEMBER 2000 seventy six how they paintings in mice: H. R. Warner, Subfield background: Use of version Organisms within the look for Human getting older Genes. Science’s SAGE KE (12 February 2003) seventy seven Holzenberger’s mice: M. Holzenberger et al, IGF-1 receptor regulates lifespan and resistance to oxidative pressure in mice. Nature, four December 2002 [e-pub sooner than print] seventy seven Researchers at Harvard: M. Bluher, B. B. Kahn, R. C. Kahn, prolonged sturdiness in Mice missing the Insulin Receptor in Adipose Tissue, technology 299 572 (2003) seventy eight “It’s wonderful”: R. J. Davenport, One for All. Science's SAGE KE (11 December 2002), http://sageke. sciencemag. org/cgi/content/full/sageke;2002/49/nf15 eighty there are lots of studies of the loose radical concept of getting older. for instance, see Biesalski HK. unfastened radical concept of getting older. Curr Opin Clin Nutr Metab Care. 2002 Jan;5(1):5-10. overview Or Kowald A. The mitochondrial thought of getting older. Biol indications Recept. 2001 May-Aug;10(3-4):162-75. evaluate. eighty one produce extra SOD: solar J, folks D, Bradley TJ, Tower J. triggered overexpression of mitochondrial Mn-superoxide dismutase extends the existence span of grownup Drosophila melanogaster. Genetics. 2002 Jun;161(2):661-72.

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